FEDGAS (Fed Gastric Dissolution Media)

$
  • Simulates stomach fluid after an FDA meal so you can investigate in vitro the effect of food on drug absorption
  • Three different pH values available: 6, 4.5 and 3
  • 900mL of FEDGAS = 1 high-fat FDA meal
  • Designed for dissolution tests with USP Apparatus 2
  • Easy to filter, simple to make
  • Includes Buffer Concentrate for instant preparation
✔ In Stock For Immediate Dispatch
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FEDGAS (Fed Gastric Dissolution Media)
From $499.99
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1 X 0L (FEDGAS6 pH6): $499.99
1 X 0L (FEDGAS45 pH4.5): $499.99
1 X 0L (FEDGAS3 pH3): $499.99
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Product Code: FEDGAS6
Makes: 6 vessels of pH6 FEDGAS (6 x 900mL)
Powder Weight: 950 g
  • Simulates stomach fluid after an FDA meal so you can investigate in vitro the effect of food on drug absorption
  • Three different pH values available: 6, 4.5 and3
  • 900mL of FEDGAS = 1 high-fat FDA meal
  • Designed for dissolution tests with USP Apparatus 2
  • Easy to filter, simple to make
  • Includes Buffer Concentrate for instant preparation
✔ In Stock For Immediate Dispatch

FEDGAS™ dissolution media simulate human stomach fluids in the fed state. 900mL of medium contains the 62.5g of fat and 62.5g of carbohydrate present in a partially digested, high-fat FDA meal. Three different pH values (6, 4.5 and 3) enable you to test various stages of stomach emptying.

Food-effect bioavailability studies (for new drugs) and fed bioequivalence studies (for generic drugs) are mandatory in most cases because food can have a significant impact on how the drug is absorbed. This is important because it can have a profound effect on drug efficacy and even safety in patients. It’s why dissolution tests in FEDGAS are so useful because they can help you understand how the drug is released in the stomach after eating a meal.

Food yellow flask and stomach

pH Flexibility

Three different pH’s enable you to test various stages of stomach emptying.

*FEDGAS pH6: simulates fluid when stomach is full (immediately after a meal) ph6

*FEDGAS pH4.5: simulates fluid when stomach is 50% empty (approx. 1-2 hours after a meal) ph45

*FEDGAS pH3: simulates fluid when stomach is 75% empty (approx. 3-6 hours after a meal) ph3

Easy Preparation

FEDGAS dissolution media can be produced in seconds and used immediately: simply mix gel and buffer and you’re ready to go. We include a bottle of Buffer Concentrate (at the relevant pH) with each pack.

fedgas bottle plus fedgas buffer bottle equal orange flask

Usability

*Suitable for all types of drugs (acids, bases, neutral and salts)

Ibuprofen Cinnarizine Exemstantane Pillman

*Compatible with USP Apparatus 2 (use 900mL of FEDGAS per dissolution vessel) and standard HPLC analytical equipment

two scientists

*Easy to filter so avoids the need for time-consuming separation techniques. We recommend using these syringe filters that we have tested fully for compatibility with the media.

Case Studies

These case studies demonstrate how FEDGAS can be used to investigate the influence of food on drug performance.

FEDGAS™ Preparation Instructions

bottle scientist with fedgas fedgas bottle

FEDGAS™ dissolution media simulate human stomach fluids in the fed state. You should use 900mL per dissolution vessel: this contains the amount of fat and carbohydrate present in a high-fat FDA meal. FEDGAS is available at 3 different pH values: 6, 4.5 and 3 (each sold separately).

Equipment

  • Calibrated balance
  • Suitable container
  • Stirrer plate and PTFE magnet

Method

ph6

To make 900mL of FEDGAS pH6:

  • Weigh 36.8g of FEDGAS Buffer Concentrate (pH6) into a suitable container
  • Add 732.6g of purified water
  • Add 153.0g of FEDGAS gel
  • Stir until mixed thoroughly. The medium will be white like milk and is ready to use

ph45

To make 900mL of FEDGAS pH4.5:

  • Weigh 36.8g of FEDGAS Buffer Concentrate (pH4.5) into a suitable container
  • Add 730.8g of purified water
  • Add 153.0g of FEDGAS gel
  • Stir until mixed thoroughly. The medium will be white like milk and is ready to use

ph3

To make 900mL of FEDGAS pH3:

  • Weigh 36.8g of FEDGAS Buffer Concentrate (pH3) into a suitable container
  • Add 729.9g of purified water
  • Add 153.0g of FEDGAS gel
  • Stir until mixed thoroughly. The medium will be white like milk and is ready to use

Usage

  • We recommend using FEDGAS dissolution medium at 37⁰C. It can be used for up to 24 hours at this temperature
  • Store the FEDGAS gel pouch in the refrigerator and use within 7 days of opening
  • Store the FEDGAS buffer bottle at room temperature
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