Food Effects & the Fed Gastric Medium

The gastrointestinal juices in the stomach, small intestine and colon are highly complex and variable. A large factor in their variability is the prandial […]

Biorelevant Dissolution, Biorelevant Solubility, Drug Development, Fasted/Fed States, Generic Drugs, Improving Bioavailability

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Comparing dissolution profiles using the similarity factor (f2)

Biorelevant generic dissolution tests are performed to examine whether the test product formulation has the same release profile as the reference drug. The similarity […]

Biorelevant Dissolution, Drug Development, Generic Drugs, Improving Bioavailability

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How GSK Used Biorelevant Media

How GlaxoSmithKline (GSK) used Biorelevant Media (FaSSIF, FeSSIF and FaSSGF) to improve the solubility and dissolution of their novel drug danirixin for improved bioavailability. […]

Biorelevant Dissolution, Biorelevant Solubility, Fasted/Fed States, Improving Bioavailability, Industrial Use, NCEs

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