Dog FaSSIF/Dog FaSSGF

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  • Makes canine FaSSIF/FaSSGF (Fasted State Simulated Intestinal/Gastric Fluids)
  • Contains sodium taurocholate, sodium taurodeoxycholate, lecithin, lysolecithin, sodium oleate
✔ In Stock For Immediate Dispatch
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Makes
Product Code
Powder Weight
Dog FaSSIF/Dog FaSSGF
From $149.99
SELECT SIZE
1 X 1L (DOGFAS01): $149.99
1 X 10L (DOGFAS02): $549.99
4 X 1L (DOGFAS04): $449.97
4 X 10L (DOGFAS05): $1649.97
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Product Code: DOGFAS01
Makes: 1L Dog FaSSIF or 50L Dog FaSSGF
Powder Weight: 7.80 g
  • Makes canine FaSSIF/FaSSGF (Fasted State Simulated Intestinal/Gastric Fluids)
  • Contains sodium taurocholate, sodium taurodeoxycholate, lecithin, lysolecithin, sodium oleate
✔ In Stock For Immediate Dispatch

If you cannot buy from our website, we also accept Purchase Orders. Please email your POs to [email protected] or fax them to +44 (0)20 7691 7784. First orders are on a proforma basis; subsequent orders will be dispatched on receipt with net 30 days payment terms.

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Which Biorelevant Medium do you want to make?

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Dog FaSSIF, Dog FaSSGF 1.5 pH and Dog FaSSGF 6.5 pH are types of Biorelevant Media that simulate canine gut fluids before eating food.

Dog FaSSIF: Dog Fasted State Simulated Intestinal Fluid
Dog FaSSGF: Dog Fasted Stated Simulated Gastric Fluid

These in vitro tools can indicate how a drug product will dissolve when it enters the gastrointestinal tract. All three media can be made from the same powder.

How much do you want to make?

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The media are usable for 48 hours from preparation.
For reasons of practicality and precision, we do not recommend making less than the following volumes:

Dog FaSSIF: 100 mL
Dog FaSSGF 1.5 pH: 1 L
Dog FaSSGF 6.5 pH: 1 L

Select hydrate type for phosphate salt (for buffer preparation)

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You can select any of the three hydrate forms for preparing your phosphate buffer, it makes no difference to the final results. Simply use the one that is most convenient for you.

Optional step: do you want to degas the buffer?

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Degassing the buffer is entirely optional. If you are using the media for dissolution testing, degassing can potentially affect how the dosage form disintegrates so you may wish to do so. However, we generally do not recommend it because degassed media reabsorb atmospheric gases rapidly and re-equilibrate quickly after degassing.

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We also accept Purchase Orders at [email protected]

SDS

Download the Safety Data Sheet for this product here

COA

Download the most recent Certificate of Analysis for this product here

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Dog FaSSIF/FaSSGF helped us to select one formulation out of several prototypes for a bioavailability study in dogs. All prototypes were tested in buffer media in advance but results were hardly discriminative due to the poor solubility of the API. We expect that the canine Biorelevant Media will also reflect the in vivo precipitation kinetics of APIs more accurately if enhanced solubility (supersaturation) is targeted.

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Dr. Marcel Arndt, Evonik Nutrition & Care GmbH, Germany

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Dog FaSSIF/FaSSGF provides a straightforward way of closely simulating a complex biological environment in an easy to use media. Use of this product reduces time and cost whilst maintaining experimental accuracy.

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Michael Barnes, Oxford University , United Kingdom

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