Dog FaSSIF/Dog FaSSGF Powder

  • Examine how an oral drug will be released from a formulation and dissolve in dog gastrointestinal fluids using rapid and cost effective in vitro studies

  • Streamline preclinical development by linking your oral drug's in vitro biorelevant solubility and dissolution to in vivo preclinical canine bioavailability

  • Makes 3 different dissolution media: Dog FaSSIF, Dog FaSSGF and Dog FaSSGF (after pentagastrin administration)

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1L size (DOGFAS01)
10L size (DOGFAS02)
4 X 1L size (DOGFAS04)
4 X 10L size (DOGFAS05)
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In stock Ready for immediate dispatch

Dog FaSSIF/Dog FaSSGF Powder

Examine how an oral drug will be released from a formulation and dissolve in canine gastrointestinal fluids

Select Pack
$149.99
1L size (DOGFAS01)
10L size (DOGFAS02)
4 X 1L size (DOGFAS04)
4 X 10L size (DOGFAS05)
Add to Cart
Need a Quote?
  • Examine how an oral drug will be released from a formulation and dissolve in dog gastrointestinal fluids using rapid and cost effective in vitro studies

  • Streamline preclinical development by linking your oral drug's in vitro biorelevant solubility and dissolution to in vivo preclinical canine bioavailability

  • Makes 3 different dissolution media: Dog FaSSIF, Dog FaSSGF and Dog FaSSGF (after pentagastrin administration)

✔ In Stock For Immediate Dispatch
Media Preparation Tool
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Product Description

Dog FaSSIF and Dog FaSSGF are dissolution media that simulate fasted canine gut fluids. These in vitro test media contain physiological surfactants (bile salts and lecithin) present in the canine gastrointestinal tract. There are actually three different test media that can be made from this product:

Dog FaSSIF: Canine Fasted State Simulated Intestinal Fluid

Dog FaSSGF: Canine Fasted State Simulated Gastric Fluid (pH 6.5)

Dog FaSSGF (pentagastrin): Canine Fasted State Simulated Gastric Fluid after administration of pentagastrin (pH 1.5)

The composition of Dog FaSSIF is quite different from the equivalent human medium because the higher level of surfactants found in dog intestinal fluid can enhance the dissolution of poorly soluble drugs. This can help you interpret preclinical canine drug bioavailability results and link dog bioavailability results to human bioavailability.  

Dog FaSSGF is also quite different from the equivalent human medium because the pH of fasted dog stomach fluid (6.5) is significantly higher than the pH of fasted human gastric fluid.

Dog FaSSGF (pentagastrin) reflects the pH of the stomach after coadminstration of pentagastrin (pH 1.5) which is used in preclinical canine studies to encourage the acidification of the stomach fluid. This is important when testing pH sensitive drugs (especially bases) as the lower pH of the fluid can increase the solubility of a drug before it enters the small intestine leading to higher absorption. The media are described in the recently added ‘USP Chapter <1236> Solubility Measurements’ to test drug solubility in canine fasted state simulated gastric fluids and intestinal fluids. There are many reasons why this product is so useful to developers of oral drugs:

*Streamlining your preclinical development by linking your drug’s in vitro biorelevant solubility and dissolution results to in vivo preclinical canine bioavailability could reduce the number of in vivo studies required

*Examine how a drug will be released from a formulation and dissolve in dog gastrointestinal fluids using rapid and cost-effective in vitro studies. This is important during preclinical formulation testing or for the development of veterinary products intended for dogs

*Ideal for use in USP 1 or USP 2 dissolution apparatus (we recommend 900mL of media per vessel)

*Drug analysis can be carried out by HPLC

*Simple and quick preparation method

*Get customized instructions explaining how to make different media volumes from our ‘Media Preparation Tool’ (see above)

*Different pack sizes available to suit your testing requirements (see top of screen)

Frequently bought together with Dog FaSSIF/Dog FaSSGF Powder
FaSSIF/FeSSIF/FaSSGF Powder
Make 3 different biorelevant media from 1 powder. Our original product used by the top 10 companies in Pharma
Syringe Filters
We recommend these glass syringe filters manufactured in the UK by Whatman for successful biorelevant testing
Frequently bought together with Dog FaSSIF/Dog FaSSGF Powder
FaSSIF/FeSSIF/FaSSGF Powder
Make 3 different biorelevant media from 1 powder. Our original product used by the top 10 companies in Pharma
Syringe Filters
We recommend these glass syringe filters manufactured in the UK by Whatman for successful biorelevant testing