Solubility tests - Covaris ultrasonicator

The Covaris apparatus can be used for small quantities of compound during early stage development. It also can reduce your experiment duration. It uses sonication, with which the wetting of the compound is improved and the equilibrium solubility of the compound is reached quickly. The temperature is controlled in a water bath.

An excess amount of compound is introduced into a vial and covered with biorelevant medium. The vial is then placed into the Covaris and the procedure is started. After test completion the sample has to be filtered. Since the volumes are usually low the filtration is performed through micropipette filter tip.


Sandra Klein: The Use of Biorelevant Dissolution Media to Forecast the In Vivo Performance of a Drug (2010)

Nikoletta Fotaki and Maria Vertzoni: Biorelevant Dissolution Methods and Their Applications in In Vitro - In Vivo Correlations for Oral Formulations (2010)