Solubility tests - µDiss Profiler

The µDiss Profiler is a multifunctional apparatus, which can be used for solubility assessment. The advantage of using µDiss is that no additional equipment is required to perform the tests. The apparatus uses fibre optics, which enable direct concentration measurement of the compound in solution. This avoids taking physical samples.

An excess amount of compound is introduced into µDiss vessels. The vials are then filled with biorelevant medium (up to 20ml). The apparatus agitates and heats the samples to the required temperature, and also performs the sample measurement at desired time points.


Sandra Klein: The Use of Biorelevant Dissolution Media to Forecast the In Vivo Performance of a Drug (2010)

Nikoletta Fotaki and Maria Vertzoni: Biorelevant Dissolution Methods and Their Applications in In Vitro - In Vivo Correlations for Oral Formulations (2010)