FASTED COLON

FaSSCoF

  • FaSSCoF is a biorelevant dissolution medium simulating human fasted state colonic fluid

  • Assess how modified release drug products intended for colonic delivery dissolve in fluids in the fasted colon

Product Description
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10L size
Product Code: COFAS01
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FASTED COLON
Pack
10L size
Product Code: COFAS01
Quantity
-
+
Total: $
$/Unit
Add to Cart
X

To get quote add to cart item(s) you require.

Get Quote
Get Quote
Send Purchase Order
X
Email Purchase Orders to [email protected]. Please include:

- A Purchase Order Number
- Shipping info: address, contact name, email and telephone
- Billing info: address, contact name, email and telephone

First orders will trigger a proforma invoice for pre-payment.
30 days net terms will apply to subsequent purchases.
Media Preparation Tool
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Product Description

FaSSCoF is a biorelevant dissolution medium that simulates human fasted state colonic fluid. It contains the appropriate physiological components (bile salt and lipids) reflecting those present in colonic fluids before a meal. This makes FaSSCoF more predictive of solubility and dissolution than plain buffers.

It is used to assess how drugs and modified release drug products intended for colonic delivery dissolve in fasted state colonic fluids. In general, it is less useful for immediate release drugs because absorption of most immediate release drugs are largely complete when the colon is reached and the zone for absorption after oral administration is much smaller than the upper gastrointestinal tract. Here are the specific benefits of using this product:

*Ideal for use in USP dissolution apparatus (if using USP dissolution 1 or USP dissolution 2 apparatus we recommend 900ml of FaSSCoF per vessel)

*Drug analysis can be carried out by HPLC

*Simple and quick preparation method

*Get customized instructions explaining how to make different FaSSCoF volumes from our ‘Media Preparation Tool’ (see above)

Frequently bought together with FaSSCoF
FeSSCoF
 A biorelevant dissolution medium simulating fed state colonic fluid to help assess how modified release drug products will dissolve
Frequently bought together with FaSSCoF
FeSSCoF
 A biorelevant dissolution medium simulating fed state colonic fluid to help assess how modified release drug products will dissolve