What is in FaSSGF?
In vivo gastric fluid in the fasted state contains low levels of surfactants refluxed back into the stomach from the upper section of the small intestine. FaSSGF (Fasted State Simulated Intestinal Fluid) contains the same type and low level of these surfactants (bile salt and phospholipid). These components can contribute to the wetting of a dosage form and drug.
FaSSGF has the average acidic pH of fasted gastric fluid and similar osmolarity too. These are important parameters to control when testing drugs or formulations sensitive to pH and salt content. The exact composition of FaSSGF is provided here:
You can make FaSSGF in an instant with our FaSSIF/FeSSIF/FaSSGF powder available here.