What is in FaSSIF?
FaSSIF (Fasted State Simulated Intestinal Fluid) contains the same type and level of surfactants (bile salt and phospholipid) present in the gastrointestinal fluid it replicates. These surfactants are critical, particularly for poorly water-soluble drugs, because they form mixed micelles which can enhance drug solubility and dissolution greatly. This can have a big influence on how a drug is absorbed.
FaSSIF has the average pH of fasted intestinal fluid and similar osmolarity too. These are important parameters to control when testing drugs or formulations sensitive to pH and salt content. The exact composition of FaSSIF is provided here:
You can make FaSSIF in an instant with our FaSSIF/FeSSIF/FaSSGF powder available here.