Why to test your oral drug in FaSSGF

FaSSGF (Fasted State Simulated Gastric Fluid) is a very useful drug development tool. Tests in this dissolution medium can help reveal how your oral drug is likely to behave in the stomach after drinking a glass of water. Although drugs are not generally absorbed in the stomach, the interaction with stomach fluid can influence the absorption of many drugs greatly; this is especially true of bases.

The stability, solubility and dissolution data you generate from testing in FaSSGF can help identify critical factors influencing your drug’s absorption in the fasted state. These results also support your selection of the appropriate solid state and formulation approach for your drug.  Experiments are performed using standard laboratory equipment (such as USP Dissolution Apparatus 1 or 2). Drug content is analysed using HPLC.

To understand how fasted state gastrointestinal fluids influence drug absorption, dissolution studies in FaSSIF (Fasted State Simulated intestinal Fluids) must also be conducted. Both FaSSGF and FaSSIF can be prepared from the same product which is available here.