Why to test your oral drug in FaSSIF
FaSSIF (Fasted State Simulated Intestinal Fluid) is a very useful drug development tool. Tests in this dissolution medium can reveal how your oral drug is likely to dissolve and potentially be absorbed in fluid from the upper intestine after drinking a glass of water.
The stability, solubility and dissolution data you generate from testing in FaSSIF can help identify critical factors influencing your drug’s absorption in the fasted state. This is especially important for water insoluble drugs. These results also support your selection of the appropriate solid state and formulation approach for your drug. Experiments are performed using standard laboratory equipment (such as USP Dissolution Apparatus 1 or 2). Drug content is analysed using HPLC.
For an even better understanding of how fasted state gastrointestinal fluids influence drug absorption, dissolution studies in FaSSGF (Fasted State Simulated Gastric Fluid) should also be conducted. Both FaSSIF and FaSSGF can be made from the same product which is available here.