Why to test your oral drug in FeSSIF

FeSSIF (Fed State Simulated Intestinal Fluid) is a very useful drug development tool. Tests in this dissolution medium can help reveal how your oral drug is likely to dissolve and potentially be absorbed in fluid from the upper intestine after eating a meal.

The stability, solubility and dissolution data you generate from testing in FeSSIF can help identify critical factors influencing your drug’s absorption in the fed state. This is especially important for water insoluble drugs. These results also support your selection of the appropriate solid state and formulation approach for your drug.  Experiments are performed using standard laboratory equipment (such as USP Dissolution Apparatus 1 or 2). Drug content is analysed using HPLC.

For an even better understanding of how fed state gastrointestinal fluids influence drug absorption, dissolution studies in FEDGAS (Fed State Simulated Gastric Fluids) should also be conducted. Both FEDGAS and the product that makes FeSSIF are available here.