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Patient Information Leaflets detail how medicines should be used

Oral drugs are generally taken with a glass of water or a meal

But food changes the composition of gastrointestinal juices a lot

This can have a big influence on how a drug behaves in the gastrointestinal tract and is absorbed by the body

Biorelevant testing enables you to simulate the complex conditions of the human gut in your laboratory

All you need to run biorelevant experiments is USP Apparatus 2 and HPLC: just switch dissolution media

Biorelevant Media

Fasted Gut

FaSSIF simulates small intestinal fluid before a meal. Drug undissolved in fasted gastric fluid must dissolve in fasted small intestinal fluid to be absorbed in vivo. In vitro dissolution tests in FaSSIF will reveal how much drug has the potential to be absorbed without food.
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FaSSGF simulates gastric fluid before a meal. Oral drugs taken in vivo without food first encounter gastric fluid. In vitro dissolution tests in FaSSGF enable the user to discover how much drug will go into solution before passing into the small intestine.
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Fed Gut

FeSSIF simulates small intestinal fluid after a meal. Drug undissolved in fed gastric fluid must dissolve in fed small intestinal fluid to be absorbed in vivo. In vitro dissolution tests in FeSSIF can reveal how much drug has the potential to be absorbed with food.
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FEDGAS simulates gastric fluid after a high-fat FDA meal. An FDA meal changes stomach fluid dramatically which can have a big effect on how the drug behaves in vivo. In vitro dissolution tests in FEDGAS will reveal how much drug dissolves in a fed stomach.
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click on different parts of the image for more info

These interactive guts explain the different types of Biorelevant Media and how they can be used

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Case Studies

These Case Studies demonstrate the huge potential value of testing oral drug products in Biorelevant Media

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Learning Centre

Visit our Learning Centre for helpful tips and techniques direct from our laboratory

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