Biorelevant Media simulate the fluids present in the gut before (fasted) and after (fed) eating food. They are really useful tools for predicting what will happen to your product after it’s swallowed. Their close similarity to what's actually inside your body makes them very helpful for Pharmaceutical companies (CROs, developers, generic drug manufacturers) and also the functional food, vitamin and medical device industries. There are even versions available to mimic the gastro-intestinal juices of different animals! We supply the powders which enable you to make Biorelevant Media quickly, easily and cost effectively.
Contents of Distal Ileum and Cecum (OrBiTo)
Contents of the healthy distal ileum and cecum had never been characterised under conditions that simulate bioavailability or bioequivalence studies. At least not until an OrBiTo study was performed by Reppas et al. (What is OrBiTo? Check our post here!)¹. They assessed composition and physicochemical parameters, such as pH and buffer capacity. They did so
Sparkling water and drug performance
It may seem odd to think about how the intake of still vs. sparkling water with an oral dosage form could make a difference on drug performance. Van den Abeele et al. studied exactly that¹. They performed in vitro dissolution testing and an in vivo study on humans for paracetamol. The interesting thing is that
Biorelevant Media and Gene Therapy
In science, we’ve all seen how gene therapy has become an extremely hot topic in recent years. Not least because of its potential ability to cure certain types of cancer. Kiani et al.’s work on colorectal cancer therapy is really quite something¹. And here’s why: it’s fascinating work not only because of the general science