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- FaSSIF-V2
Media Preparation Tool
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PRODUCT DESCRIPTION
FaSSIF-V2 is a biorelevant dissolution medium that simulates human fasted state intestinal fluid.
Although FaSSIF-V2 was introduced after FaSSIF, it is not superior to the original medium. It contains the same physiological surfactants as FaSSIF but in a slightly different bile salt to lecithin ratio.
If you are a new user of biorelevant media, we would recommend you start with our best seller FaSSIF/FeSSIF/FaSSGF which enables you to produce 3 different biorelevant media from the same powder (you cannot do so with this FaSSIF-V2 product). We also supply a range of buffer concentrates for it (sold separately) which make preparation of these media even quicker, easier and more reproducible than ever before. Nevertheless, FaSSIF-V2 is still an exceptionally useful testing medium if you are developing an oral drug:
*As with FaSSIF, it can help you gain in vitro insights into drug solubility and dissolution in the small intestine before a meal
*FaSSIF-V2 is described in the recently introduced “USP Chapter <1236> Solubility measurements” as one of the recommended biorelevant media for testing drug solubility in human fasted state simulated intestinal fluid
*Ideal for use in USP1 or USP2 dissolution apparatus (we recommend 900mL of FaSSIF-V2 per vessel)
*Drug analysis can be carried out by HPLC
*Simple and quick preparation method
*Get customized instructions explaining how to make different FaSSIF-V2 volumes from our Media Preparation Tool (see above)
*Different pack sizes available to suit your testing requirements (see top of screen)
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TECHNICAL INFO
*Homogenous powder containing physiologically relevant levels of high purity bile salt and lecithin
*Packed in a sealed white HDPE container with protective moisture absorbent
*Country of Manufacture: UK
*HS Code: 3822.0000
*Supplied with Certificate of Analysis and SDS (see below)
*Transported at ambient temperature. Refrigerate for long-term storage
*Unopened pack has a shelf life of at least 12 months
*Media suitable for use up to 48 hours after preparation
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SDS/COA
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Testimonials
I think that FaSSIF is a very special and original product and it's very important for our lab research to help create new medicines.
The biorelevant.com media are easy to make and use. In particular, I appreciate that they remain usable for 48 hours; many of my experiments last either 24 or 48 hours, so that stability is essential to obtaining real results.
Very good product, especially comparing with traditional FaSSIF preparation.
These powders are so easy to use: after a quick test to confirm compatibility, they should be used in all cell monolayer permeability transport studies!
FaSSIF-V2 powder is incredibly easy to use and the long shelf-life helps to minimize waste. FaSSIF-V2 is a convenient choice of biorelevant media for use in GI dissolution and supersaturation experiments where in-situ UV absorbance measurement is required.
It really meets my needs... good service, especially the fast delivery.
FaSSIF-V2 is very user friendly. Good explanation on the preparation and the fast delivery is very appreciated!
I've always gotten reliable and reproducible data with the products that helped the formulations department better adjust their experiments to produce desired dissolution profiles. Love the wide range of media as well!
