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FaSSIF-V2
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Use FaSSIF-V2 Powder with matching Buffer Concentrate for instant medium preparation and maximum reproducibility
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Use Media Preparation Tool below for customized preparation instructions
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Custom Syringe Filters available in packs of 72 pieces
55g of powder makes 30 litres of FaSSIF-V2
FaSSIF-V2= Fasted State Simualted Intestinal Fluid Version Two
Use with FaSSIF-V2 Powder
280g of buffer concentrate makes 6 litres of buffer solution
For filtration of dissolution samples <5mL we recommend 13mm version
For filtration of dissolution samples >5mL we recommend 25mm version
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Product Description
FaSSIF-V2 is a biorelevant dissolution medium that simulates human fasted state intestinal fluid.
Although FaSSIF-V2 was introduced after FaSSIF, it is not superior to the original medium. It contains the same physiological surfactants as FaSSIF but in a slightly different bile salt to lecithin ratio.
If you are a new user of biorelevant media, we would recommend you start with our best seller FaSSIF/FeSSIF/FaSSGF which enables you to produce 3 different biorelevant media from the same powder (you cannot do so with this FaSSIF-V2 product). Nevertheless, FaSSIF-V2 is still an exceptionally useful testing medium if you are developing an oral drug:
*As with FaSSIF, it can help you gain in vitro insights into drug solubility and dissolution in the small intestine before a meal
*FaSSIF-V2 is described in the recently introduced “USP Chapter <1236> Solubility measurements” as one of the recommended biorelevant media for testing drug solubility in human fasted state simulated intestinal fluid
*Ideal for use in USP1 or USP2 dissolution apparatus (we recommend 900mL of FaSSIF-V2 per vessel)
*Drug analysis can be carried out by HPLC
*Simple and quick preparation method
*Get customized instructions explaining how to make different FaSSIF-V2 volumes from our Media Preparation Tool (see above)
