- Makes the second version of FaSSIF (Fasted State Simulated Intestinal Fluid)
- Contains biological surfactants (taurocholic acid sodium salt, lecithin)
- Safety Data Sheet
- Certificate of Analysis
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What is FaSSIF-V2?
It’s a ‘biorelevant’ dissolution medium that simulates human gut fluid before eating food:
- FaSSIF: Fasted State Simulated Intestinal Fluid
Testing your product in Biorelevant Media can help predict what will happen when it enters the gastro-intestinal tract. This is because the media are physiologically discriminating: they contain biological surfactants (sodium taurocholate and lecithin) that can have a big impact on drug solubility. Conventional buffers and surfactants (such as sodium lauryl sulfate) do not replicate the complex environment of the GI tract anywhere near as accurately.
Why do I need them?
Testing in physiologically relevant media can help determine:
Biorelevant solubility: how much drug dissolves in the Biorelevant Medium
Estimated cost: $1.12 (based on 2 glass vials of 5ml FaSSIF-V2 made from V2FAS01)
Biorelevant dissolution: how much time drug takes to dissolve in the Biorelevant Medium
Estimated cost: $36 (based on 6 dissolution vessels of 500ml FaSSIF-V2 made from V2FAS03)
These in vitro tests can significantly reduce the amount of costly in vivo experiments needed because they can help you identify promising drug candidates and distinguish good formulations from bad ones.
How do I make it?
We use the highest grade of ingredients and analyze their purity before manufacture. The powders are made in our factory in London where we carefully control every aspect of their production. They are only released after rigorous analysis by a GMP certified laboratory in Germany. All products are supplied with a Certificate of Analysis. These steps ensure you will get highly reproducible results from our products every time you use them.
FaSSIF-V2 is very user friendly. Good explanation on the preparation and the fast delivery is very appreciated!
Novartis Pharma AG, Switzerland
The biorelevant.com media are easy to make and use. In particular, I appreciate that they remain usable for 48 hours; many of my experiments last either 24 or 48 hours, so that stability is essential to obtaining real results.
Princeton University, USA
I think that FaSSIF is a very special and original product and it's very important for our lab research to help create new medicines.
Petr Hrabal, Zentiva k.s., Czech Republic
Very good product, especially comparing with traditional FaSSIF preparation.
Sandra Rodríguez Ponce, Uriach , Spain
These powders are so easy to use: after a quick test to confirm compatibility, they should be used in all cell monolayer permeability transport studies!
Dr. Steven C. Sutton, Assoc. Prof of Pharmaceutics, USA
FaSSIF-V2 powder is incredibly easy to use and the long shelf-life helps to minimize waste. FaSSIF-V2 is a convenient choice of biorelevant media for use in GI dissolution and supersaturation experiments where in-situ UV absorbance measurement is required.
Dr. Rebeca Ruiz, Sirius Analytical, United Kingdom
It really meets my needs... good service, especially the fast delivery.
Ding Xin, IBN, Singapore, Singapore
I've always gotten reliable and reproducible data with the products that helped the formulations department better adjust their experiments to produce desired dissolution profiles. Love the wide range of media as well!
Theravance Biopharma, USA