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- FeSSIF-V2
Media Preparation Tool
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PRODUCT DESCRIPTION
FeSSIF-V2 is a biorelevant dissolution medium that simulates human fed state intestinal fluid. It is quite similar to FeSSIF but contains lipolysis products of fat digestion. This could help you understand more clearly the solubility and dissolution of lipophilic drugs (Log D ≥ 3) in the fed state intestine in vivo. It’s a very useful tool for new and generic developers of an oral drug:
*FeSSIF-V2 is described in the recently introduced ‘USP Chapter <1236> Solubility measurements’ as a recommended biorelevant medium for testing drug solubility in human fed state simulated intestinal fluid
*Ideal for use in USP 1 or USP 2 dissolution apparatus (we recommend 900ml of FeSSIF-V2 per vessel)
*Drug analysis can be carried out by HPLC
*Simple and quick preparation method
*Get customized instructions explaining how to make different FeSSIF-V2 volumes from our ‘Media Preparation Tool’ (see above)
*Different pack sizes available to suit your testing requirements (see top of screen)
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TECHNICAL INFO
*Homogenous powder containing physiologically relevant levels of high purity bile salt, lecithin and digestive components
*Packed in a sealed white HDPE container with protective moisture absorbent
*Country of Manufacture: UK
*HS Code: 3822.0000
*Supplied with Certificate of Analysis and SDS (see below)
*Transported at ambient temperature. Refrigerate for long-term storage
*Unopened pack has a shelf life of at least 12 months
*Media suitable for use up to 48 hours after preparation
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SDS/COA
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Testimonials
We have used it frequently in our lab for more than a year because this ‘ready-to-use’ FeSSIF-V2 can be easily reproduced even for small volumes (i.e. for solubility purposes) compared with the conventional prepared media which require multiple ingredients to be sourced and use up a lot of analytical time. Of course, we are pleased to use FeSSIF-V2 powder for simulating fed conditions since it makes our ‘lab job’ so much easier! Thank you for existing!
Trying to convince people that we should use biorelevant media in order to accurately predict the in vivo situation is one thing, but knowing that these media are also easy to make should convince everybody to work with it. Even in fed state media (where we are dealing with a complex intraluminal environment), biorelevant.com has now launched the new FeSSIF-V2 which can lead to more optimized predictions in postprandial conditions.
The products are perfect... we are very pleased with them and the service offered.
I've always gotten reliable and reproducible data with the products that helped the formulations department better adjust their experiments to produce desired dissolution profiles. Love the wide range of media as well!
We have found the FeSSIF V2 powder to be easy to use and dependable. Your online instructions for making buffers are straightforward and easy to understand. We will no doubt keep using your products in future research.
