Biorelevant.com Learning Centre

 General
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What are biorelevant media?

Biorelevant media simulate gut fluids more accurately than any other dissolution media. They contain components (bile salts, phospholipids and salts) …

 General
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How biorelevant media can help develop new drugs (NCEs)

Whether you're a chemist, biologist or pharmacist involved in the development a new oral drug (NCE: New Chemical Entity), biorelevant …

 General
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How biorelevant media can help develop bioequivalent generic drugs

Testing in biorelevant media cenables you to compare how closely your test drug product will match the dissolution of the …

 FaSSIF
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Why to test your oral drug in FaSSIF

FaSSIF (Fasted State Simulated Intestinal Fluid) is a very useful drug development tool. Tests in this dissolution medium can reveal …

 FaSSIF
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What is in FaSSIF?

FaSSIF (Fasted State Simulated Intestinal Fluid) contains the same type and level of surfactants (bile salt and phospholipid) present in …

 FaSSIF
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How to make FaSSIF

You can make FaSSIF in no more than a couple of minutes with FaSSIF/FeSSIF/FaSSGF Powder and FaSSIF Buffer Concentrate. These …

 FeSSIF
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Why to test your oral drug in FeSSIF

FeSSIF (Fed State Simulated Intestinal Fluid) is a very useful drug development tool. Tests in this dissolution medium can help …

 FeSSIF
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What is in FeSSIF?

In response to eating a meal, the upper intestines secrete surfactants (bile salt and phospholipid) to help break the food …

 FeSSIF
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How to make FeSSIF

You can make FeSSIF in no more than a couple of minutes with FaSSIF/FeSSIF/FaSSGF Powder and FeSSIF Buffer Concentrate. These …

 FaSSGF
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Why to test your oral drug in FaSSGF

FaSSGF (Fasted State Simulated Gastric Fluid) is a very useful drug development tool. Tests in this dissolution medium can help …

 FaSSGF
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What is in FaSSGF?

In vivo gastric fluid in the fasted state contains low levels of surfactants refluxed back into the stomach from the …

 FaSSGF
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How to make FaSSGF

You can make FaSSGF in no more than a couple of minutes with FaSSIF/FeSSIF/FaSSGF Powder and FaSSGF Buffer Concentrate. These …

 FEDGAS
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Why to test your oral drug in fed state stomach fluids

FEDGAS (Fed State Simulated Gastric Fluid AKA FeSSGF) is a very useful drug development tool. Tests in these dissolution media …

 FEDGAS
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How to make FEDGAS

FEDGAS simulates stomach fluids after a high-fat FDA meal. The 3 different versions (Early/Mid/Late) reflect various stages of stomach emptying …

 FEDGAS
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What is in FEDGAS?

FEDGAS in vitro test solutions simulate stomach fluids after consumption of a high-fat FDA meal. The FDA meal is frequently …

 Tips
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How to analyse your drug in biorelevant media

Analysis of your drug in biorelevant media is straightforward; the method required should be similar to those used for analysing …

 Tips
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Selecting the right syringe filter

To achieve reliable dissolution results, selection of the right filter is important. There is not one single filter that works …

 FEDGAS
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FeSSGF vs FEDGAS: a comparison

In vitro dissolution testing of drugs in media that simulate in vivo gastric fluids after a meal can be very …

 Tips
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Recommended equipment for biorelevant dissolution

Selection of equipment for your biorelevant tests is dependent upon the type of experiment you want to carry out. For …

 Tips
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Biorelevant Dissolution Test Method

We have developed a biorelevant dissolution test method that is very easy to follow and uses standardized USP 1 or …