• Makes FeSSCoF (Fed State Simulated Colonic Fluid)
  • Contains sodium cholate, sodium oleate, lecithin
✔ In Stock For Immediate Dispatch
Product Code
Powder Weight
Shelf Life 18 Months
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  • Safety Data Sheet
  • Certificate of Analysis
  • Instructions

If you cannot buy from our website, we also accept Purchase Orders. Please email your POs to [email protected] or fax them to +44 (0)20 7691 7784. First orders are on a proforma basis; subsequent orders will be dispatched on receipt with net 30 days payment terms.

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What is FeSSCoF?

It’s a ‘biorelevant’ dissolution medium that simulates human colonic fluid after eating food:

  • FeSSCoF: Fed State Simulated Colonic Fluid

Testing your product in Biorelevant Media can help predict what will happen when it enters the gastro-intestinal tract. This is because the media are physiologically discriminating: they contain biological surfactants (bile salts and lecithin) that can have a big impact on drug solubility. Conventional buffers and surfactants (such as sodium lauryl sulfate) do not replicate the complex environment of the GI tract anywhere near as accurately.

FeSSCoF is particularly useful for testing products with an 'extended release' dosage form where absorption in the colon is targeted.

Why do I need it?

Testing in physiologically relevant media can help determine:
Biorelevant solubility: how much drug dissolves in the Biorelevant Medium
Estimated cost: $0.40 (based on 2 glass vials of 10ml FeSSCoF made from COFES01)

Biorelevant dissolution: how much time drug takes to dissolve in the Biorelevant Medium
Estimated cost: $45 (based on 6 dissolution vessels of 500ml FeSSCoF made from COFES02)

These in vitro tests can significantly reduce the amount of costly in vivo experiments needed because they can help you identify promising drug candidates and distinguish good formulations from bad ones.

How do I make it?

Very easily!

Reproducible results

We use the highest grade of ingredients and analyze their purity before manufacture. The powders are made in our factory in London where we carefully control every aspect of their production. They are only released after rigorous analysis by a GMP certified laboratory in Germany. All products are supplied with a Certificate of Analysis. These steps ensure you will get highly reproducible results from our products every time you use them.


I've always gotten reliable and reproducible data with the products that helped the formulations department better adjust their experiments to produce desired dissolution profiles. Love the wide range of media as well!

Theravance Biopharma, USA