Canine FaSSIF/FaSSGF

  • Examine how an oral drug will be released from a formulation and dissolve in canine gastrointestinal fluids using rapid and cost effective in vitro studies

  • Streamline preclinical development and reduce canine preclinical testing by linking your oral drug's in vitro biorelevant solubility and dissolution to in vivo preclinical canine bioavailability

  • Makes 3 different dissolution media: Canine FaSSIF, Canine FaSSGF (pH 1.5) and Canine FaSSGF (pH 6.5)

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1) Buy Powder:

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1) Buy Powder:

K9 Powder
K9FAS
24g
In stock
$499.99
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2) Choose Buffer Concentrate(s):

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2) Choose Buffer Concentrate(s):

  • Simulate different regions of the canine gastrointestinal tract

  • Use in combination with K9 Powder

FaSSIF-K9 Buffer
K9FASBUF
270g
FaSSGF-K9 Buffer (pH6.5)
K9FASGBUF6.5
260g
FaSSGF-K9 Buffer (pH1.5)
K9FASGBUF1.5
250g
In stock
$29.99
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In stock
$29.99
- +
In stock
$29.99
- +

3) Add Syringe Filters:

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High filtration efficiency with minimal risk of clogging or bursting

Low drug adsorption and negligible extractables

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X

High filtration efficiency with minimal risk of clogging or bursting

Low drug adsorption and negligible extractables

>
<

3) Add Syringe Filters:

  • For filtration of dissolution samples <5mL we recommend 13mm version

  • For filtration of dissolution samples >5mL we recommend 25mm version

Dissolution Filters 13mm
GMF13
72 pieces
Dissolution Filters 25mm
GMF25
72 pieces
In stock
$199.99
Buy 4, Save 25%
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In stock
$199.99
Buy 4, Save 25%
- +

**Choose Buffer Concentrates:

**Choose Buffer Concentrates:

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Canine FaSSIF and Canine FaSSGF are dissolution media that simulate fasted canine gut fluids. These in vitro test media contain physiological surfactants (bile salts and lecithin) present in a dog's gastrointestinal tract. There are three different test media that can be made from this product and the corresponding buffer concentrates:

FaSSIF-K9: Canine Fasted State Simulated Intestinal Fluid
FaSSGF-K9 (pH 1.5): Canine Fasted State Simulated Gastric Fluid after administration of pentagastrin (pH 1.5)
FaSSGF-K9 (pH 6.5): Canine Fasted State Simulated Gastric Fluid (pH 6.5)

These media are used during pre-clinical formulation development of NCEs as well as for the development of veterinary products intended for canine companions. The composition of these media is distinct from the equivalent human versions because the higher level of surfactants found in dog intestinal fluid can enhance the dissolution of poorly soluble drugs. This can help you interpret pre-clinical canine drug bioavailability results more effectively and link canine bioavailability results to human bioavailability.

FaSSGF-K9 (pH 6.5) is also quite different from the equivalent human medium because the pH of fasted dog stomach fluid is typically mucb higher than the pH of fasted human gastric fluid. This can significantly influence the canine in vivo absorption of bases compared to humans.

FaSSGF-K9 (pH 1.5) reflects the pH of the canine stomach fluid after co-administration of pentagastrin which is used in preclinical canine studies to encourage the acidification of the stomach fluid. This is important when testing pH sensitive drugs (especially bases) as the lower pH of the fluid can increase the solubility of a drug before it enters the small intestine leading to higher absorption.

These media are described in the recently added ‘USP Chapter <1236> Solubility Measurements’.