Examine how an oral drug will be released from a formulation and dissolve in canine gastrointestinal fluids using rapid and cost effective in vitro studies
Streamline preclinical development by linking your oral drug's in vitro biorelevant solubility and dissolution to in vivo preclinical canine bioavailability
Makes 3 different dissolution media: FaSSIFc, FaSSGFc pH 1.5 and FaSSGFc pH 6.5
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Canine FaSSIF and Canine FaSSGF are dissolution media that simulate fasted canine gut fluids. These in vitro test media contain physiological surfactants (bile salts and lecithin) present in a dog's gastrointestinal tract. There are actually three different test media that can be made from this product:
FaSSIFc: Canine Fasted State Simulated Intestinal Fluid
FaSSGFc pH 1.5: Canine Fasted State Simulated Gastric Fluid after administration of pentagastrin (pH 1.5)
FaSSGFc pH 6.5: Canine Fasted State Simulated Gastric Fluid (pH 6.5)
The composition of these media is quite different from the equivalent human versions because the higher level of surfactants found in dog intestinal fluid can enhance the dissolution of poorly soluble drugs. This can help you interpret preclinical canine drug bioavailability results and link canine bioavailability results to human bioavailability.
FaSSGFc pH 6.5 is also quite different from the equivalent human medium because the pH of fasted dog stomach fluid is significantly higher than the pH of fasted human gastric fluid.
FaSSGFc pH 1.5 reflects the pH of the stomach after coadminstration of pentagastrin which is used in preclinical canine studies to encourage the acidification of the stomach fluid. This is important when testing pH sensitive drugs (especially bases) as the lower pH of the fluid can increase the solubility of a drug before it enters the small intestine leading to higher absorption. The media are described in the recently added ‘USP Chapter <1236> Solubility Measurements’ to test drug solubility in canine fasted state simulated gastric fluids and intestinal fluids. There are many reasons why this product is so useful to developers of oral drugs:
*Streamlining your preclinical development by linking your drug’s in vitro biorelevant solubility and dissolution results to in vivo preclinical canine bioavailability could reduce the number of in vivo studies required
*Examine how a drug will be released from a formulation and dissolve in dog gastrointestinal fluids using rapid and cost-effective in vitro studies. This is important during preclinical formulation testing or for the development of veterinary products intended for dogs
*Ideal for use in USP 1 or USP 2 dissolution apparatus (we recommend 900mL of media per vessel)
*Drug analysis can be carried out by HPLC
*Simple and quick preparation method
*Get customized instructions explaining how to make different media volumes from our ‘Media Preparation Tool’ (see above)