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Entry Level Experiment

Dissolution of a neutral drug in fasted state biorelevant media

Background

For an orally administered drug to be absorbed, it must first be released from its formulation and dissolve in the fluids present in the gastrointestinal tract. The way a drug behaves in fasted state gastrointestinal fluids can strongly influence how much drug and how quickly the drug becomes available for absorption after administration with a glass of water. To investigate this process, simple in vitro dissolution tests can be performed using biorelevant media. These tests use conventional HPLC analysis and USP dissolution apparatus with vessels containing media that simulate the fluids found in the stomach and upper intestinal tract under fasted state conditions. There is no need for specialist equipment.