FEDGAS

  • Biorelevant dissolution media simulating gastric fluids after food

  • Excellent discriminatory power for neutral, basic or acidic BCS Class 2 drugs

  • Reduce the risk of bioequivalence (BE) failures for water insoluble drugs

  • 3 different pH’s (6, 4.5 and 3) reflect different stages of stomach emptying

  • Designed for use in standard USP Dissolution 1 and 2 apparatus

  • Step-by-step Experiment Guide available for download on our Home page

Product Description

1) Buy Gel

  • Use with diluted Buffer Concentrates (available below) for instant media prep

  • FEDGAS Gel (1kg) makes 6L of Fed State Gastric Dissolution Media

FEDGAS Gel
Product Code: FDG-GEL
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$499.99
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$399.99
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1) Buy Gel

  • Use with diluted Buffer Concentrates (available below) for instant media prep

  • FEDGAS Gel (1kg) makes 6L of Fed State Gastric Dissolution Media

FEDGAS Gel
Product Code: FDG-GEL
Quantity
1+
$499.99
Save 0%
3+
$399.99
Save 21%
-
+
Total: $
$/Unit
Add to Cart
X

To get quote add to cart item(s) you require.

Get Quote
Get Quote
Send Purchase Order
X
Email Purchase Orders to [email protected]. Please include:

- A Purchase Order Number
- Shipping info: address, contact name, email and telephone
- Billing info: address, contact name, email and telephone

First orders will trigger a proforma invoice for pre-payment.
30 days net terms will apply to subsequent purchases.

2) Choose Buffer Concentrates:

  • Must be used in combination with FEDGAS Gel (available above)

  • Choose from 3 different pH values

  • Each bottle of Buffer Concentrate (250g) makes 6L of buffer

pH6 FEDGAS Buffer Concentrate (Early)
Product Code: FDG-BUF6
pH4.5 FEDGAS Buffer Concentrate (Mid)
Product Code: FDG-BUF4.5
pH3 FEDGAS Buffer Concentrate (Late)
Product Code: FDG-BUF3
Quantity
-
+
Total: $
$/Unit
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X
Email Purchase Orders to [email protected]. Please include:

- A Purchase Order Number
- Shipping info: address, contact name, email and telephone
- Billing info: address, contact name, email and telephone

First orders will trigger a proforma invoice for pre-payment.
30 days net terms will apply to subsequent purchases.
Send Purchase Order
In stock
In stock

2) Choose Buffer Concentrates:

Product Code:

  • Must be used in combination with FEDGAS Gel (available above)

  • Choose from 3 different pH values

  • Each bottle of Buffer Concentrate (250g) makes 6L of buffer

pH6 FEDGAS Buffer Concentrate (Early)
Product Code: FDG-BUF6
pH4.5 FEDGAS Buffer Concentrate (Mid)
Product Code: FDG-BUF4.5
pH3 FEDGAS Buffer Concentrate (Late)
Product Code: FDG-BUF3
Quantity
-
+
Total: $
$/Unit
Add to Cart
X

To get quote add to cart item(s) you require.

Get Quote
Get Quote
Send Purchase Order
X
Email Purchase Orders to [email protected]. Please include:

- A Purchase Order Number
- Shipping info: address, contact name, email and telephone
- Billing info: address, contact name, email and telephone

First orders will trigger a proforma invoice for pre-payment.
30 days net terms will apply to subsequent purchases.

3) Add Syringe Filters:

  • For filtration of dissolution samples <5mL we recommend 13mm version

  • For filtration of dissolution samples >5mL we recommend 25mm version

  • Available in packs of 36 pieces for immediate dispatch
GMF Syringe Filters 13mm
Product Code: GMF-13
GMF Syringe Filters 25mm
Product Code: GMF-25
Quantity
1+
$99.99
4+
$79.99
Save 21%
1+
$99.99
4+
$79.99
Save 21%
-
+
Total: $
$/Unit
X

To get quote add to cart item(s) you require.

Add to Cart
Get Quote
Get Quote
X
Email Purchase Orders to [email protected]. Please include:

- A Purchase Order Number
- Shipping info: address, contact name, email and telephone
- Billing info: address, contact name, email and telephone

First orders will trigger a proforma invoice for pre-payment.
30 days net terms will apply to subsequent purchases.
Send Purchase Order
In stock
In stock

3) Add Syringe Filters:

Product Code:

  • For filtration of dissolution samples <5mL we recommend 13mm version

  • For filtration of dissolution samples >5mL we recommend 25mm version

  • Available in packs of 36 pieces for immediate dispatch
GMF Syringe Filters 13mm
Product Code: GMF-13
GMF Syringe Filters 25mm
Product Code: GMF-25
Quantity
1+
$99.99
Save 0%
4+
$79.99
Save 21%
1+
$99.99
Save 0%
4+
$79.99
Save 21%
-
+
Total: $
$/Unit
Add to Cart
X

To get quote add to cart item(s) you require.

Get Quote
Get Quote
Send Purchase Order
X
Email Purchase Orders to [email protected]. Please include:

- A Purchase Order Number
- Shipping info: address, contact name, email and telephone
- Billing info: address, contact name, email and telephone

First orders will trigger a proforma invoice for pre-payment.
30 days net terms will apply to subsequent purchases.

Our Experiment Guide is so easy to follow

Download it on the home page!

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FEDGAS simulates fed state gastric fluids. You can harness its power in your laboratory to discriminate significant formulation differences between your Test Product and the Reference. 900ml of this biorelevant dissolution medium contains the 62.5g of fat present in the high-fat meal along with bile salts present at physiological levels found in the fed stomach. Testing in it is particularly useful for lipophilic water insoluble drugs because good physiological dissolution conditions are created for these drugs.

Three types of fed state gastric media (at pH 6, pH 4.5 and pH 3) can easily be prepared using FEDGAS Gel and the appropriate diluted FEDGAS Buffer Concentrate. These three dissolution media reflect the different states of stomach emptying:

Generating and comparing dissolution profiles in the right biorelevant media helps reduce the risk of an expensive failed human bioequivalence study due to differences in formulation. Matching the dissolution profile of your Test Formulation to the Originator in FEDGAS will maximise the chances of achieving successful bioequivalence. In vitro biorelevant dissolution helps identify a Test formulation that matches the release rate of the Reference in vivo.

You can download a step-by-by step FEDGAS Dissolution Experiment Guide here.