FaSSIF/FeSSIF/FaSSGF
Use 3F Powder + Buffer Concentrates to make FaSSIF, FeSSIF or FaSSGF
3F Powder contains bile salts + lecithin to form gastrointestinal mixed micelles
Use Media Preparation Tool below for customized preparation instructions
Custom Syringe Filters available in packs of 72 pieces
1) Buy Powder:
70g of 3F Powder makes FaSSIF (30L) or FeSSIF (6L) or FaSSGF (>1000L)
2) Choose Buffer Concentrate(s):
FaSSIF/FeSSIF/FaSSGF Buffer Concentrates make up the 3 different buffer solutions in seconds
3) Add Syringe Filters:
For filtration of dissolution samples <5mL we recommend 13mm version
For filtration of dissolution samples >5mL we recommend 25mm version
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Product Description
FaSSIF, FeSSIF and FaSSGF are dissolution media that simulate human gut fluids:
FaSSIF: Fasted State Simulated Intestinal Fluid
FeSSIF: Fed State Simulated Intestinal Fluid
FaSSGF: Fasted State Simulated Gastric Fluid
They contain physiological surfactants (bile salts and lecithin) present in the gastrointestinal tract to simulate these fluids much more accurately than conventional dissolution media.
We’ve been producing FaSSIF/FeSSIF/FaSSGF (originally known as ‘SIF Powder’) for more than a decade and it’s trusted by the 10 biggest Pharmaceutical companies in the world as the industrial standard for preparing biorelevant test media. Its versatility and ease of use make it the perfect introduction to biorelevant testing. Here’s why the product is so useful to both new and generic developers of oral drugs:
*In vitro solubility results in biorelevant media help establish a relationship between the biopharmaceutical properties of an oral drug and in vivo absorption
*In vitro dissolution results in biorelevant media can enable drug developers to identify test formulations with superior dissolution profiles
*Ideal for use in USP 1 or USP 2 dissolution apparatus (we recommend 900mL of media per vessel)
*Drug analysis can be carried out by HPLC
*Standardized preparation method is extremely fast and simple and results in highly reproducible media every time
*Get customized instructions explaining how to make different FaSSIF/FeSSIF/FaSSGF volumes from our ‘Media Preparation Tool’ (see above)