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Glass Microfibre Syringe Filters
Designed for both fasted and fed state biorelevant dissolution media
High filtration capacity with minimal risk of clogging or bursting
Low drug adsorption and negligible extractables
Glass Microfibre (GMF) 13mm or 25mm filter diameter available
Easy to handle 25mm casing for both filter diameters
Custom-made in the UK to Biorelevant's exact specifications
Certificate of Conformity available
Choose Diameter:
For filtration of dissolution samples <5mL we recommend 13mm
For filtration of dissolution samples >5mL we recommend 25mm
72 pieces per pack
Terminate dissolution
Using the right filter for dissolution sampling can make a big difference to your biorelevant results. When carrying out dissolution runs, samples taken from each vessel at the defined time points must be filtered punctually to remove any undissolved (solid) drug to terminate the dissolution process immediately.
Two filter diameters available
A suitable filter for dissolution should be efficient, reproducible, have low drug adsorption and not leach extractables, clog or burst. A 0.45µm pore size is generally best for testing drugs with biorelevant media in standard USP vessels. These filters are available in two diameters: 13 mm and 25 mm. Low volume sampling is recommended to keep the amount of medium in the dissolution vessel at a high and consistent volume which is why we recommend the use of the 13 mm diameter filter. However, if you prefer to take larger sample volumes (>5 mL) then a GMF filter with 25 mm diameter is also available.
Fresh filter
For optimal dissolution results, we strongly recommend using a fresh filter at each sampling time point to halt the dissolution process. This is why we offer the filters in packs of 72 pieces.
Certificate of conformity
We developed our Biorelevant syringe filters in conjunction with Cytiva who also manufacture them for us in the UK. Each batch comes with a certificate of conformity; they have a good flow rate, low hold up volume, low retention and should not clog, even when sampling high dose insoluble drugs.
