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FaSSIF simulates small intestinal fluid before a meal. Drug undissolved in fasted gastric fluid must dissolve in fasted small intestinal fluid to be absorbed in vivo. In vitro dissolution tests in FaSSIF will reveal how much drug has the potential to be absorbed without food.
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FaSSGF simulates gastric fluid before a meal. Oral drugs taken in vivo without food first encounter gastric fluid. In vitro dissolution tests in FaSSGF enable the user to discover how much drug will go into solution before passing into the small intestine.
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FeSSIF simulates small intestinal fluid after a meal. Drug undissolved in fed gastric fluid must dissolve in fed small intestinal fluid to be absorbed in vivo. In vitro dissolution tests in FeSSIF can reveal how much drug has the potential to be absorbed with food.
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FEDGAS simulates gastric fluid after a high-fat FDA meal. An FDA meal changes stomach fluid dramatically which can have a big effect on how the drug behaves in vivo. In vitro dissolution tests in FEDGAS will reveal how much drug dissolves in a fed stomach.
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FaSSGF simulates gastric fluid before a meal. Oral drugs taken in vivo without food first encounter gastric fluid. In vitro dissolution tests in FaSSGF enable the user to discover how much drug will go into solution before passing into the small intestine.
FaSSIF simulates small intestinal fluid before a meal. Drug undissolved in fasted gastric fluid must dissolve in fasted small intestinal fluid to be absorbed in vivo. In vitro dissolution tests in FaSSIF will reveal how much drug has the potential to be absorbed without food.
FeSSIF simulates small intestinal fluid after a meal. Drug undissolved in fed gastric fluid must dissolve in fed small intestinal fluid to be absorbed in vivo. In vitro dissolution tests in FeSSIF can reveal how much drug has the potential to be absorbed with food.
FEDGAS simulates gastric fluid after a high-fat FDA meal. An FDA meal changes stomach fluid dramatically which can have a big effect on how the drug behaves in vivo. In vitro dissolution tests in FEDGAS will reveal how much drug dissolves in a fed stomach.
