Testing exemestane solubility and dissolution in biorelevant media
Drug: exemestane tablet
Therapeutic category: anti-cancer
Food effect: positive
BCS classification: class 2
In vitro biorelevant solubility and dissolution tests were conducted on the steroidal anticancer molecule exemestane (reference drug product Aromasin) and a generic formulation widely marketed in Europe. These biorelevant tests were able to detect a significant difference in vitro between originator and test formulation. This difference was also translated in vivo when the bioavailability of the two exemestane tablets was tested.
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