FaSSIF-V2 is a biorelevant dissolution medium that simulates human fasted state intestinal fluid.
Although FaSSIF-V2 was introduced after FaSSIF, it is not superior to the original medium. It contains the same physiological surfactants as FaSSIF but in a slightly different bile salt to lecithin ratio.
If you are a new user of biorelevant media, we would recommend you start with our best seller FaSSIF/FeSSIF/FaSSGF which enables you to produce 3 different biorelevant media from the same powder (you cannot do so with this FaSSIF-V2 product). We also supply a range of buffer concentrates for it (sold separately) which make preparation of these media even quicker, easier and more reproducible than ever before. Nevertheless, FaSSIF-V2 is still an exceptionally useful testing medium if you are developing an oral drug:
*As with FaSSIF, it can help you gain in vitro insights into drug solubility and dissolution in the small intestine before a meal
*FaSSIF-V2 is described in the recently introduced “USP Chapter <1236> Solubility measurements” as one of the recommended biorelevant media for testing drug solubility in human fasted state simulated intestinal fluid
*Ideal for use in USP1 or USP2 dissolution apparatus (we recommend 900mL of FaSSIF-V2 per vessel)
*Drug analysis can be carried out by HPLC
*Simple and quick preparation method
*Get customized instructions explaining how to make different FaSSIF-V2 volumes from our Media Preparation Tool (see above)
*Different pack sizes available to suit your testing requirements (see top of screen)