Why to include Biorelevant Media in working standards (WS)

Analysis

It is important to include a biorelevant medium when diluting the secondary standard (SS) as it keeps the matrix of the working standard (WS) and biorelevant dissolution samples similar. Inclusion of the biorelevant medium helps identify if HPLC injection of the working standard (WS) at the desired wavelength (nm) has any additional (non-drug) peaks and biorelevant medium peaks which could potentially interfere with drug analysis.

You can download our Biorelevant Dissolution Guides here.