Checking interference by injecting the dosage form in biorelevant medium
Interference of non-drug peaks (originating for example from excipients) should also be evaluated via specificity and precision using a sample which contains the dosage form. This sample can be prepared with a crushed dosage form. This sample should be injected multiple times and checked that non-drug peaks (e.g. diluent, excipients and medium) do not interfere with drug peak.