In vitro dissolution testing of drugs in media that simulate in vivo gastric fluids after a meal can be very useful, especially for poorly soluble drugs (BCS Classes 2 and 4).

FeSSGF (Fed State Simulated Gastric Fluid) is based on milk and has been proposed for dissolution testing but has distinct limitations for laboratory use. FEDGAS (Fed Gastric) media was developed by Biorelevant to overcome the limitations of FeSSGF as this comparison table of their respective properties demonstrates:

Figure 1 Physical stability of FeSSGF                                                                                                                                                             

FeSSGF (pH adjusted to 4.5) at t=0 hours                         FeSSGF (pH adjusted to 4.5) at t=24 hours

Figure 1 Physical stability of FEDGAS Mid*

FEDGAS Mid at t=0 hours                                          FEDGAS Mid at t=24 hours

*Early and Late versions are the same stability

The high fat content of FEDGAS and ability to test across all stages of stomach emptying enable you to explore the dissolution of your drug’s dosage form in a way that has never previously been possible with fed state media. Together with simple dissolution results in FaSSGF/FaSSIF/FeSSIF, the dissolution data from this food effect media can help you develop a clearer understanding of the drug absorption process from gut fluids, assess potential food effects and support you in the optimization of your drug product.

You can learn more about FEDGAS and purchase the product here.