Which ingredients are in FaSSIF-V2 Powder?

FaSSIF-V2 Powder contains the ingredients sodium taurocholate, lecithin.  This powder is used to prepare biorelevant medium FaSSIF-V2 which simulates the second version of fasted state intestinal fluids. This reflects the intestinal fluid that the dosage form encounters after administration with a glass of water but no food.

USP Chapter <1236> Solubility

The composition of FaSSIF-V2 is referenced in the USP Chapter <1236> Solubility: subsection “Solubility Measurements in Biorelevant Media”.
We have modified and improved the buffer composition, but the physiological surfactants are identical.
The quantitative composition of the ingredients in FaSSIF-V2 are provided in the Table below.


How do I make FaSSIF-V2?

This fasted state in vitro test medium is prepared in no more than a couple of minutes with FaSSIF-V2 Powder (V2FAS) and our diluted FaSSIF-V2 Buffer Concentrate (V2FASBUF). These simple steps show how easy it is to prepare 900mL of the medium (the volume we generally recommend using per dissolution vessel):

Use our Media Prep Tool to download instructions of how to prepare the volume of FaSSIF-V2 medium you require.

Information on our FaSSIF-V2 Buffer Concentrate and the physico-chemical properties of FaSSIF-V2 can be found here.

Technical Data Sheets, Certificates of Analysis and Safety Data Sheets which can also be downloaded from our homepage.