Importance of filtration in dissolution sample preparation for HPLC analysis

Filtration is a crucial step in preparing a dissolution sample. It involves passing the sample through a filter to separate solid particles or undissolved materials from the liquid portion of the sample which contains dissolved drug.

This is why filtration is so vital:

  • It is needed to achieve accurate and precise results in analytical dissolution testing
  • Filtration stops the dissolution process in the sample by removing any undissolved drug particles
  • It also helps prevent clogging of the HPLC column and autosampler
  • Filtration removes insoluble excipients, which are inactive ingredients in the sample, further protecting the HPLC equipment

Download our Biorelevant Dissolution Guides here.