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ALL NEW! Background Analysis Dissolution Filters Biorelevant media
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NEW!
Dissolution
Biorelevant media

How food can affect drugs in the FED stomach

In patients with a healthy stomach, a high-fat meal can have multiple...
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Biorelevant media

Introducing Biorelevant Media

How matching dissolution profiles in Biorelevant Media will help identify which Test Formulation will be bioequivalent to the Reference
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Biorelevant media

Introducing FaSSIF

Generating in vitro dissolution profiles of a Test Product and Reference in this Biorelevant Medium reveals the rates of drug release in vivo
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Biorelevant media

Introducing FeSSIF

FeSSIF (Fed State Simulated Intestinal Fluid) is a biorelevant test medium that replicates biliary secretions present in small intestinal fluid after eating food
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Biorelevant media

Introducing FaSSGF

Although drugs are not generally absorbed in the stomach, the interaction with stomach fluid can influence the solubility and dissolution of many drugs greatly and impact on the subsequent absorption
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Biorelevant media

Introducing FEDGAS

FEDGAS dissolution media contain the full level of fat of an FDA meal along with carbohydrates, water soluble fibre and the low level of bile salts that is present in actual fed state stomach fluid due to intestinal reflux
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Dissolution
Biorelevant media

Biorelevant Media: Discriminatory Dissolution Tools

Interaction of formulations with physiological components of Biorelevant Media mimic wetting and dissolution processes that occur in vivo
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Biorelevant media

What is in FaSSIF?

FaSSIF (Fasted State Simulated Intestinal Fluid) is a very useful drug development tool. Tests in this dissolution medium can reveal how your oral drug is likely to dissolve and potentially be absorbed in fluid from the upper intestine...
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Biorelevant media

What is FeSSIF?

FeSSIF (Fed State Simulated Intestinal Fluid) is a very useful drug development tool. Tests in this dissolution medium can help …
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Biorelevant media

What is FaSSGF?

FaSSGF (Fasted State Simulated Gastric Fluid) is a very useful drug development tool. Tests in this dissolution medium can help …
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Biorelevant media

What is FEDGAS?

FEDGAS (Fed State Simulated Gastric Fluid AKA FeSSGF) is a very useful drug development tool. Tests in these dissolution media …
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Biorelevant media

FeSSGF vs FEDGAS: a comparison

In vitro dissolution testing of drugs in media that simulate in vivo gastric fluids after a meal can be very …
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Biorelevant media

How biorelevant media can help develop new drugs (NCEs)

Whether you're a chemist, biologist or pharmacist involved in the development a new oral drug (NCE: New Chemical Entity), biorelevant …
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Biorelevant media

An improved buffer concentrate for preparation of FaSSIF-V2

An improved buffer concentrate for preparation of FaSSIF-V2 has been developed to overcome the limitations of the previous maleic acid buffer system.
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Biorelevant media

An improved Buffer Concentrate for preparation of FeSSIF-V2

An improved Buffer Concentrate for preparation of FeSSIF-V2 has been developed to overcome the limitations of the previous maleic acid buffer system.
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Biorelevant media

Composition and properties of FaSSIF, FeSSIF and FaSSGF Media prepared from 3F Powder and Buffer Concentrates

FaSSIF, FeSSIF and FaSSGF dissolution media are prepared by diluting FaSSIF, FeSSIF, FaSSGF Buffer Concentrates with water and adding the required amount of 3F Powder®.
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Biorelevant media

pH reproducibility of FaSSIF, FeSSIF and FaSSGF prepared from 3F Powder® and corresponding Buffer Concentrates

Variable pH of a solubility or dissolution medium is one of the most common and significant reasons for irreproducible results which affects decision making and interpretation.
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Biorelevant media

Which ingredients are in FeSSIF-V2 Powder?

This post describes the ingredients in this fed state biorelevant intestinal medium and its preparation.
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Biorelevant media

Which ingredients are in FaSSIF-V2 Powder?

Which ingredients are in FaSSIF-V2 Powder?
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NEW!
Dissolution
Biorelevant media

What is Canine FaSSIF and Canine FaSSGF?

Learn about the three types of canine biorelevant media