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Biorelevant media
Dissolution tips

How can biorelevant media be discriminatory?

When selected and used correctly, Biorelevant Media are perfect discriminatory dissolution tools for evaluating a Test formulation against the Originator.
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Biorelevant media

How Biorelevant Media can help develop generic drugs

In vitro dissolution profiles of a Test Formulation vs the Reference in Biorelevant Media will reveal how similar drug release and dissolution rates will be in vivo.
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Biorelevant media

How Biorelevant Media can help develop new drugs (NCEs)

Biorelevant tests provide important information on the amount of drug (solubility) and speed (dissolution) at which NCEs will dissolve within gastrointestinal fluids.
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Biorelevant media

The importance of using Biorelevant's Buffer Concentrates

Biorelevant’s Buffer Concentrates have been designed to be used with our powders to provide a simple and accurate way of preparing biorelevant dissolution media.
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Biorelevant media

pH reproducibility of FaSSIF/FeSSIF/FaSSGF made from 3F Powder + Buffer Concentrates

Maintaining a consistent pH is essential to achieve reproducible solubility and dissolution results of drugs that have different aqueous solubility in the physiological range of the human gut.
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Biorelevant media

What is FaSSIF?

FaSSIF (Fasted State Simulated Intestinal Fluid) is a biorelevant test medium that replicates small intestinal fluid after drinking a glass of water.
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Biorelevant media

What is the composition of FaSSIF?

FaSSIF contains the same type and level of surfactants (bile salt and phospholipid) present in the gastrointestinal fluid it replicates.
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Biorelevant media

What is FeSSIF?

FeSSIF (Fed State Simulated Intestinal Fluid) is a biorelevant test medium that replicates biliary secretions present in small intestinal fluid after eating food.
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Biorelevant media

What is the composition of FeSSIF?

In response to eating a meal, the upper intestines secrete surfactants (bile salt and phospholipid) to help break the food down. FeSSIF contains the same types and levels of these surfactants.
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Biorelevant media

What is FaSSGF?

FaSSGF (Fasted State Simulated Gastric Fluid) is a biorelevant test medium that replicates gastric fluid after drinking a glass of water.
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Biorelevant media

What is the composition of FaSSGF?

In vivo gastric fluid in the fasted state contains low levels of surfactants refluxed back into the stomach from the upper section of the small intestine. FaSSGF contains the same type and low level of these surfactants (bile salt and phospholipid).
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Biorelevant media

What is a High-Fat FDA meal?

A High-Fat FDA meal is a standardized meal that is orally administered along with a drug product to create fed state/condition in human clinical trials.
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Biorelevant media

How can food affect drugs in the fed stomach?

In patients with a healthy stomach, a high-fat meal can have multiple effects on the stomach and its fluids.
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Biorelevant media

What is FEDGAS?

FEDGAS (Fed Gastric Fluid) biorelevant media are analytical laboratory test solutions that simulate different types of stomach fluids after eating an FDA meal.
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Biorelevant media

What is the composition of FEDGAS?

FEDGAS in vitro test solutions simulate stomach fluids after consumption of a high-fat FDA meal. 900mL of FEDGAS medium contains the same amount of fat present in this meal.
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Biorelevant media

FeSSGF vs FEDGAS: a comparison

FeSSGF (Fed State Simulated Gastric Fluid) vs FEDGAS (from Biorelevant): comparing physical stability, reproducibility, fat content, filterability and usability.
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Biorelevant media

Which ingredients are in FaSSIF-V2 Powder?

Which ingredients are in FaSSIF-V2 Powder?
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Biorelevant media

Biorelevant's improved buffer for FaSSIF-V2

Biorelevant has developed an improved buffer concentrate for preparation of FaSSIF-V2 to overcome the limitations of the previous maleic acid buffer system.
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Biorelevant media

Which ingredients are in FeSSIF-V2 Powder?

This post describes the ingredients in this fed state biorelevant intestinal medium and its preparation.
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Biorelevant media

An improved Buffer Concentrate for preparation of FeSSIF-V2

An improved Buffer Concentrate for preparation of FeSSIF-V2 has been developed to overcome the limitations of the previous maleic acid buffer system.
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Biorelevant media
Dissolution tips

What is Canine FaSSIF and Canine FaSSGF?

Learn about the three types of canine biorelevant media