Filtration of drugs in fed state media: Is filter adsorption required?

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Filter adsorption studies are performed to determine whether the drug is adsorbed onto a filter during dissolution sample filtration which can result in underestimation of dissolution results.
If biorelevant GMF13 filters are used for separating undissolved drug from the dissolution samples, usually filter adsorption is not required. This is because a total sampling volume of 5 mL (4 mL discard volume and 1 mL analytical sample volume) is typically sufficient to saturate the filter for most drugs in fed-state biorelevant dissolution media.
If filters other than biorelevant GMF13 are used in the biorelevant fed state dissolution experiment or the sampling volume is less than 4mL, filter adsorption study should be performed as described here.