It may seem odd to think about how the intake of still vs. sparkling water with an oral dosage form could make a difference on drug performance. Van den Abeele et al. studied exactly that¹. They performed in vitro dissolution testing and an in vivo study on humans for paracetamol. The interesting thing is that they found that paracetamol intake with sparkling water improves its performance.
How is this? Well, by making its absorption in the gut faster and less variable. This suggests that drug disposition in the gut is steadier than with still water. Why is this? Potentially, because of more reproducible disintegration of the tablet in the stomach, which could result in a change in dissolution rate and/or gut motility. We find this this kind of research intriguing, as it helps expand our knowledge of oral drug performance in vivo.
1. Van Den Abeele, J., Brouwers, J., Deloose, E., Tack, J. & Augustijns, P. The Effect of Sparkling Water on Intraluminal Formulation Behaviour and Systemic Drug Performance. J. Pharm. Sci. (2017). doi:10.1016/j.xphs.2017.03.039