Why Biorelevant Dissolution samples should be diluted for HPLC analysis
Without dilution, drugs which are poorly water soluble may precipitate from biorelevant medium at room temperature after sampling.
Importance of filtration in dissolution sample preparation for HPLC analysis
Filtration is a crucial step in preparing a dissolution sample. It involves passing the sample through a filter to separate solid particles or undissolved materials...
When is a filter adsorption study necessary?
Filter adsorption studies should always be conducted before dissolution studies are carried out when a) a new drug is being tested or b) a different biorelevant medium is being used.
Two-stage biorelevant dissolution
This experiment simulates the in vivo process when a drug product is transferred from the fasted stomach to the fasted intestine.