Learning Centre

What is FaSSIF?
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FaSSIF (Fasted State Simulated Intestinal Fluid) is a very useful drug development tool. Tests in this dissolution medium can reveal …

What is FeSSIF?
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FeSSIF (Fed State Simulated Intestinal Fluid) is a very useful drug development tool. Tests in this dissolution medium can help …

What is FaSSGF?
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FaSSGF (Fasted State Simulated Gastric Fluid) is a very useful drug development tool. Tests in this dissolution medium can help …

What is FEDGAS?
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FEDGAS (Fed State Simulated Gastric Fluid AKA FeSSGF) is a very useful drug development tool. Tests in these dissolution media …

FeSSGF vs FEDGAS: a comparison
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In vitro dissolution testing of drugs in media that simulate in vivo gastric fluids after a meal can be very …

How to analyse your drug in Biorelevant Media
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After drug separation, the medium (containing dissolved drug) is best analysed by HPLC. HPLC avoids potential interference of the media and can identify possible drug instability
How biorelevant media can help develop new drugs (NCEs)
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Whether you're a chemist, biologist or pharmacist involved in the development a new oral drug (NCE: New Chemical Entity), biorelevant …

Composition and physico-chemical properties of FaSSIF-V2
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An improved buffer concentrate for preparation of FaSSIF-V2 has been developed to overcome the limitations of the previous maleic acid buffer system.
HPLC Parameters using FaSSIF-V2
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Comparing HPLC profiles of FaSSIF-V2 made using Buffer Concentrate versus FaSSIF-V2 made using buffer from scratch
Dissolution profiles in FaSSIF-V2
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Ibuprofen, Carbamazepine and Diclofenac dissolution profiles in FaSSIF-V2
Composition and physico-chemical properties of FeSSIF-V2
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An improved Buffer Concentrate for preparation of FeSSIF-V2 has been developed to overcome the limitations of the previous maleic acid buffer system.
HPLC Parameters using FeSSIF-V2
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To compare the HPLC profiles of FeSSIF-V2 prepared using a) FeSSIF-V2 Powder with FeSSIF-V2 Buffer Concentrate and b) FeSSIF-V2 Powder with buffer made from scratch, the following HPLC in-house method has been used throughout the different experiments.
Dissolution profiles in FeSSIF-V2
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Dissolution runs, using USP Dissolution Apparatus 2, were carried out at 37°C with 900mL of the FeSSIF-V2 media.
Composition and properties of FaSSIF, FeSSIF and FaSSGF Media prepared from 3F Powder and Buffer Concentrates
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FaSSIF, FeSSIF and FaSSGF dissolution media are prepared by diluting FaSSIF, FeSSIF, FaSSGF Buffer Concentrates with water and adding the required amount of 3F Powder®.
pH reproducibility of FaSSIF, FeSSIF and FaSSGF prepared from 3F Powder® and corresponding Buffer Concentrates
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Variable pH of a solubility or dissolution medium is one of the most common and significant reasons for irreproducible results which affects decision making and interpretation.