Learning Centre

What is filter compatibility and why is it so important?
Tip Image
There are two aspects of filter compatibility that the dissolution scientist should consider...
Sample requirements for a drug filter adsorption study
Tip Image
To conduct a drug filter adsorption study, typically, a sample representing around 10% to 20% of drug release from the immediate-release dosage form in the dissolution vessel is needed.
What is 'specificity'?
Tip Image
Specificity is an integral part of analytical method validation and must be performed by carrying out multiple injections to eliminate potential errors that can occur during experimental sequence.
What is 'precision'?
Tip Image
The degree of deviation between a set of measurements obtained from multiple analysis of the same homogenous sample under the specified conditions expresses the precision of an analytical method.
Why are specificity and precision required with biorelevant media?
Tip Image
Biorelevant dissolution media contain natural surfactants which can affect chromatographic properties leading to erroneous analytical results.
When is a filter adsorption study necessary?
Tip Image
Filter adsorption studies should always be conducted before dissolution studies are carried out when a) a new drug is being tested or b) a different biorelevant medium is being used.
Key requirements for filters used in biorelevant dissolution testing
Tip Image
We recommend the use of glass filters with pre-filters built-in. These filters have excellent efficiency in removing particles and do not leach substances into the biorelevant media.