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ALL Background Analysis Dissolution Filters Biorelevant media NEW!
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Importance of filtration in dissolution sample preparation for HPLC analysis
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Filtration is a crucial step in preparing a dissolution sample. It involves passing the sample through a filter to separate solid particles or undissolved materials...
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When is a filter adsorption study necessary?
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Filter adsorption studies should always be conducted before dissolution studies are carried out when a) a new drug is being tested or b) a different biorelevant medium is being used.
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Two-stage biorelevant dissolution
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This experiment simulates the in vivo process when a drug product is transferred from the fasted stomach to the fasted intestine.
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How to apply a washing cycle when running an HPLC sequence
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How to apply a washing cycle when running an HPLC sequence
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Signs of column deterioration
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Explains what the common indicators of HPLC column deterioration look like
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How to store HPLC columns after using Biorelevant Media
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How to store HPLC columns in the short, mid- and long term after using Biorelevant Media
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Coning of immediate release drug products in a USP 2
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Coning of immediate release drug products is a problem
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What are the signs of coning
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Signs and examples of coning in a USP 2 dissolution vessel
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PEAK (Apex) dissolution vessels
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This post explains what PEAK (Apex) vessels
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What are ghost peaks and why do they occur?
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This post describes potential causes of ghost peaks when analysing a drug in biorelevant medium
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What is supersaturation of a drug substance?
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This post explains supersaturation of a drug substance
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What is equilibrium solubility of a drug?
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This post explains equilibrium solubility of a drug substance in a test medium
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USP <1236>: Solubility Measurements Chapter
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This post summarises USP Chapter <1236>