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ALL Background Analysis Dissolution Filters Biorelevant media NEW!

Importance of filtration in dissolution sample preparation for HPLC analysis

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Filtration is a crucial step in preparing a dissolution sample. It involves passing the sample through a filter to separate solid particles or undissolved materials...

When is a filter adsorption study necessary?

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Filter adsorption studies should always be conducted before dissolution studies are carried out when a) a new drug is being tested or b) a different biorelevant medium is being used.

Two stage biorelevant dissolution

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This in vitro experiment simulates the in vivo process when fasted stomach fluid (FaSSGF) containing a drug product is converted to fasted intestinal fluid (FaSSIF).

How to apply a washing cycle when running an HPLC sequence

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How to apply a washing cycle when running an HPLC sequence

Signs of column deterioration

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Explains what the common indicators of HPLC column deterioration look like

How to store HPLC columns after using Biorelevant Media

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How to store HPLC columns in the short, mid- and long term after using Biorelevant Media

Coning of immediate release drug products in a USP 2

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Coning of immediate release drug products is a problem

What are the signs of coning

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Signs and examples of coning in a USP 2 dissolution vessel

PEAK (Apex) dissolution vessels

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This post explains what PEAK (Apex) vessels

What are ghost peaks and why do they occur?

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This post describes potential causes of ghost peaks when analysing a drug in biorelevant medium

What is supersaturation of a drug substance?

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This post explains supersaturation of a drug substance

What is equilibrium solubility of a drug?

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This post explains equilibrium solubility of a drug substance in a test medium

USP <1236>: Solubility Measurements Chapter

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This post summarises USP Chapter <1236>

Filter design for two-stage biorelevant dissolution testing

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Filters design for two stage dissolution testing

pH reproducibility of Two Stage Biorelevant Dissolution Kit

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Learn about pH of FaSSGF and FaSSIF prepared from the Two Stage Biorelevant Dissolution Kit